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Intramucosal Adenocarcinoma

MedGen UID:
459346
•Concept ID:
C2987120
•
Neoplastic Process

Definition

A neoplastic lesion that shows morphologic evidence of invasion into the lamina propria or muscularis mucosa. There is no evidence of invasion into the submucosa. Evidence of invasion may refer to stromal invasion by single cells or clusters of cells, presence of atypical and complex glandular architectural patterns beyond those that are present in normal mucosa, desmoplasia, and/or vascular invasion. [from NCI]

Professional guidelines

PubMed

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Endoscopic Treatment of High-Grade Dysplasia and Early Esophageal Cancer.
Schlottmann F, Patti MG, Shaheen NJ
World J Surg 2017 Jul;41(7):1705-1711. doi: 10.1007/s00268-017-3977-8. PMID: 28275832
Surgical Management of Barrett's Esophagus.
Peyre CG, Watson TJ
Gastroenterol Clin North Am 2015 Jun;44(2):459-71. Epub 2015 Mar 24 doi: 10.1016/j.gtc.2015.02.013. PMID: 26021205

Recent clinical studies

Etiology

Endoscopic features of buried Barrett's mucosa.
Yang LS, Holt BA, Williams R, Norris R, Tsoi E, Cameron G, Desmond P, Taylor ACF
Gastrointest Endosc 2021 Jul;94(1):14-21. Epub 2020 Dec 26 doi: 10.1016/j.gie.2020.12.031. PMID: 33373645
Endoscopic or Surgical Resection for Gastro-Esophageal Cancer.
Gockel I, Hoffmeister A
Dtsch Arztebl Int 2018 Aug 6;115(31-32):513-519. doi: 10.3238/arztebl.2018.0513. PMID: 30149830Free PMC Article
Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.
Schlottmann F, Patti MG
J Gastrointest Surg 2017 Aug;21(8):1354-1360. Epub 2017 Mar 28 doi: 10.1007/s11605-017-3371-8. PMID: 28353175
Endoscopic Treatment of High-Grade Dysplasia and Early Esophageal Cancer.
Schlottmann F, Patti MG, Shaheen NJ
World J Surg 2017 Jul;41(7):1705-1711. doi: 10.1007/s00268-017-3977-8. PMID: 28275832
Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction.
Li ZG, Zhu H, Shi H, Xie H, Goldblum JR, Thota PN, Liu X
J Dig Dis 2015 Apr;16(4):197-204. doi: 10.1111/1751-2980.12230. PMID: 25620066

Diagnosis

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Endoscopic or Surgical Resection for Gastro-Esophageal Cancer.
Gockel I, Hoffmeister A
Dtsch Arztebl Int 2018 Aug 6;115(31-32):513-519. doi: 10.3238/arztebl.2018.0513. PMID: 30149830Free PMC Article
Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.
Schlottmann F, Patti MG
J Gastrointest Surg 2017 Aug;21(8):1354-1360. Epub 2017 Mar 28 doi: 10.1007/s11605-017-3371-8. PMID: 28353175
Endoscopic Treatment of High-Grade Dysplasia and Early Esophageal Cancer.
Schlottmann F, Patti MG, Shaheen NJ
World J Surg 2017 Jul;41(7):1705-1711. doi: 10.1007/s00268-017-3977-8. PMID: 28275832
Current issues in Barrett's esophagus and Barrett's-related dysplasia.
Goldblum JR
Mod Pathol 2015 Jan;28 Suppl 1:S1-6. doi: 10.1038/modpathol.2014.125. PMID: 25560595

Therapy

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Endoscopic or Surgical Resection for Gastro-Esophageal Cancer.
Gockel I, Hoffmeister A
Dtsch Arztebl Int 2018 Aug 6;115(31-32):513-519. doi: 10.3238/arztebl.2018.0513. PMID: 30149830Free PMC Article
Endoscopic Treatment of High-Grade Dysplasia and Early Esophageal Cancer.
Schlottmann F, Patti MG, Shaheen NJ
World J Surg 2017 Jul;41(7):1705-1711. doi: 10.1007/s00268-017-3977-8. PMID: 28275832
Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma.
Greene CL, Worrell SG, Attwood SE, Chandrasoma P, Chang K, DeMeester TR, Lord RV, Montgomery E, Pech O, Vallone J, Vieth M, Wang KK, DeMeester SR
J Gastrointest Surg 2016 Apr;20(4):851-60. Epub 2015 Dec 21 doi: 10.1007/s11605-015-3056-0. PMID: 26691147
Surgical Management of Barrett's Esophagus.
Peyre CG, Watson TJ
Gastroenterol Clin North Am 2015 Jun;44(2):459-71. Epub 2015 Mar 24 doi: 10.1016/j.gtc.2015.02.013. PMID: 26021205

Prognosis

Clinicopathologic correlations of superficial esophageal adenocarcinoma in endoscopic submucosal dissection specimens.
Dhingra S, Bahdi F, May SB, Othman MO
Diagn Pathol 2021 Nov 27;16(1):111. doi: 10.1186/s13000-021-01169-1. PMID: 34838082Free PMC Article
Endoscopic features of buried Barrett's mucosa.
Yang LS, Holt BA, Williams R, Norris R, Tsoi E, Cameron G, Desmond P, Taylor ACF
Gastrointest Endosc 2021 Jul;94(1):14-21. Epub 2020 Dec 26 doi: 10.1016/j.gie.2020.12.031. PMID: 33373645
Pancreatobiliary maljunction: association with gallbladder cancer.
Garzón Benavides M, Núñez Ortiz A, López Ruiz T, Cepeda Franco C, Gómez Izquierdo L
Rev Esp Enferm Dig 2019 Jul;111(7):568-570. doi: 10.17235/reed.2019.6127/2018. PMID: 31215211
Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction.
Li ZG, Zhu H, Shi H, Xie H, Goldblum JR, Thota PN, Liu X
J Dig Dis 2015 Apr;16(4):197-204. doi: 10.1111/1751-2980.12230. PMID: 25620066
Endoscopic resection and ablation versus esophagectomy for high-grade dysplasia and intramucosal adenocarcinoma.
Zehetner J, DeMeester SR, Hagen JA, Ayazi S, Augustin F, Lipham JC, DeMeester TR
J Thorac Cardiovasc Surg 2011 Jan;141(1):39-47. Epub 2010 Nov 5 doi: 10.1016/j.jtcvs.2010.08.058. PMID: 21055772

Clinical prediction guides

Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Clinicopathologic correlations of superficial esophageal adenocarcinoma in endoscopic submucosal dissection specimens.
Dhingra S, Bahdi F, May SB, Othman MO
Diagn Pathol 2021 Nov 27;16(1):111. doi: 10.1186/s13000-021-01169-1. PMID: 34838082Free PMC Article
Endoscopic features of buried Barrett's mucosa.
Yang LS, Holt BA, Williams R, Norris R, Tsoi E, Cameron G, Desmond P, Taylor ACF
Gastrointest Endosc 2021 Jul;94(1):14-21. Epub 2020 Dec 26 doi: 10.1016/j.gie.2020.12.031. PMID: 33373645
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction.
Li ZG, Zhu H, Shi H, Xie H, Goldblum JR, Thota PN, Liu X
J Dig Dis 2015 Apr;16(4):197-204. doi: 10.1111/1751-2980.12230. PMID: 25620066

Recent systematic reviews

Efficacy of Cryotherapy as a Primary Endoscopic Ablation Modality for Dysplastic Barrett's Esophagus and Early Esophageal Neoplasia: A Systematic Review and Meta-Analysis.
Tariq R, Enslin S, Hayat M, Kaul V
Cancer Control 2020 Jan-Dec;27(1):1073274820976668. doi: 10.1177/1073274820976668. PMID: 33297725Free PMC Article
Persistent intestinal metaplasia after endoscopic eradication therapy of neoplastic Barrett's esophagus increases the risk of dysplasia recurrence: meta-analysis.
Sawas T, Alsawas M, Bazerbachi F, Iyer PG, Wang KK, Murad MH, Katzka DA
Gastrointest Endosc 2019 May;89(5):913-925.e6. Epub 2018 Dec 7 doi: 10.1016/j.gie.2018.11.035. PMID: 30529044
Endoscopic eradication therapy for mucosal neoplasia in Barrett's esophagus.
Dunbar KB
Curr Opin Gastroenterol 2013 Jul;29(4):446-53. doi: 10.1097/MOG.0b013e3283622848. PMID: 23703368

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